Af17 Deficiency Increases Sodium Excretion and Decreases Blood Pressure
نویسندگان
چکیده
منابع مشابه
Sodium excretion and blood pressure.
The urinary excretion of sodium, potassium, and water during three 24-hour periods were related to blood pressure in a sample of 49-year-old men. Of 3205 49-year-old men liring in Goteborg, 2376 (74%) took part in the blood pressure screening, and, of these, 120 subjects having blood pressures from the lowest to the highest were selected by systematic sampling based on diastolic blood pressure....
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The two-kidney, one-clip renovascular (2K1C) hypertension model is characterized by a reduction in renal flow on the clipped artery that activates the renin-angiotensin system. Endothelium dysfunction, including diminished nitric oxide production, is also believed to play a role in the pathophysiology of this model. Some studies have shown an effect of L-arginine (L-Arg, a nitric oxide precurso...
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More than 30 years ago, Guyton1 described pressurenatriuresis: increasing arterial blood pressure promotes sodium excretion, decreasing blood volume and lowering blood pressure, whereas when blood pressure falls, sodium excretion decreases, and blood volume and blood pressure increase.1,2 The linchpin of the model of Guyton et al3 is the concept of feedback gain. Gain is the degree to which a f...
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ATP and UTP are endogenous agonists of P2Y(2/4) receptors. To define the in vivo effects of P2Y(2) receptor activation on blood pressure and urinary excretion, we compared the response to INS45973, a P2Y(2/4) receptor agonist and UTP analog, in wild-type (WT) and P2Y(2) receptor knockout (P2Y(2)-/-) mice. INS45973 was administered intravenously as a bolus injection or continuous infusion to det...
متن کاملSodium excretion and racial differences in ambulatory blood pressure patterns.
The influence of Na+ excretion and race on casual blood pressure and ambulatory blood pressure patterns was examined in a biracial sample of healthy, normotensive children and adolescents (10-18 years; n = 140). The slopes relating 24-hour urinary Na+ excretion to systolic blood pressure were different for both black and white subjects for casual blood pressure (p less than 0.001) and blood pre...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2011
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2010121270